A PAN-TUMOR-SIRNA APTAMER CHIMERA TO BLOCK NONSENSE-MEDIATED MRNA DECAY INFLAMES AND SUPPRESSES TUMOR PROGRESSION

A pan-tumor-siRNA aptamer chimera to block nonsense-mediated mRNA decay inflames and suppresses tumor progression

Immune-checkpoint blockade (ICB) therapy has changed the clinical outcome Shirts Men’s of many types of aggressive tumors, but there still remain many cancer patients that do not respond to these treatments.There is an unmet need to develop a feasible clinical therapeutic platform to increase the rate of response to ICB.Here we use a previously d

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Fetal Calf Serum Exerts an Inhibitory Effect on Replication of Duck Hepatitis A Virus Genotype 1 in Duck Embryo Fibroblast Cells

Among the causative agents of duck viral hepatitis, duck hepatitis A virus genotype 1 (DHAV-1) is the most common virus reported in most outbreaks worldwide.How to propagate DHAV-1 in cell cultures efficiently remains a problem to be explored.Here, we aimed to test the effect of serum type on DHAV-1 replication in duck embryo fibroblast (DEF) cells

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The case study of 10 historical gardens in the Banat region

The object of the research is developed around the historical gardens belonging to certain historical monuments, more precisely in relation to the palaces and manors of aristocratic families from the Banat area.These gardens are selected according to certain criteria that preserve physical and documentary stylistic and memorial values.The aim of th

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